Humans evolved with their microbiomes.  Like genes, gut microbes pass from one generation to the next

Humans evolved with their microbiomes. Like genes, gut microbes pass from one generation to the next

Read Time:4 Minute, 50 Second

Credit: CC0 Public Domain

When early humans moved out of Africa, they brought their gut microbes with them. It turns out that these microbes also evolved alongside them.

the human gut microbiome consists of hundreds to thousands of species of bacteria and archaea. Within a given species of microbe, different strains carry different genes that can affect your health and the diseases to which you are susceptible.

There are pronounced variation in the microbial composition and the diversity of the gut microbiome among people living in different countries around the world. Although researchers are beginning to understand what factors affect the composition of the microbiome, such as diet, there is still limited understanding of why different groups have different strains of the same species of microbes in their guts.

We are researchers who study microbial evolution Y microbiomes. Our recently published study found that microbes not only diversified with their early modern human hosts as they traveled around the world, but continued human evolution restricting itself to life in the gut.

Microbes share evolutionary history with humans

We hypothesized that as humans spread across the globe and diversified genetically, so did the microbial species in their guts. In other words, gut microbes and their human hosts “co-diversified” and evolved together, just as humans diversified so that people in Asia look different than those in Europe, so did their microbiomes.

To evaluate this, we needed to match Human genome and microbiome data from people around the world. However, the data sets that provided both the microbiome data and the genome information of individuals was limited when we began this study. Most of the publicly available data came from North America and Western Europe, and we needed data that was more representative of populations around the world.

So our research team used existing data from Cameroon, South Korea, and the UK, and also recruited mothers and their young children in Gabon, Vietnam, and Germany. We collected saliva samples from adults to determine their genotype, or genetic characteristics, and fecal samples to sequence the genomes of their gut microbes.

For our analysis, we used data from 839 adults and 386 children. To assess the evolutionary histories of humans and gut microbes, we created phylogenetic trees for each person and also for 59 strains of the most common microbial species.






The gut microbiome plays a key role in many areas of your health.

When we compared human trees to microbial trees, we discovered a gradient of how well they matched. Some bacterial trees did not match human trees at all, while others matched very well, indicating that these species co-diversified with humans. Some microbial species, in fact, have been on the evolutionary path for more than hundreds of thousands of years.

We also found that microbes that co-evolved with people have a unique set of genes and traits compared to microbes that have not co-diversified with people. Microbes that were associated with humans have smaller genomes and higher sensitivity to oxygen and temperature, mostly unable to tolerate conditions below human body temperature.

In contrast, gut microbes with weaker links to human evolution have traits and genes characteristic of free-living bacteria in the external environment. This finding suggests that co-diversified microbes are highly dependent on the environmental conditions of the human body and must be rapidly transmitted from one person to another, either from generation to generation or between people living in the same communities.

Confirming this mode of transmission, we found that mothers and their children had the same strains of microbes in their intestines. Microbes that did not co-diversify, by contrast, were more likely to survive well outside the body and can be more widely transmitted through water and soil.

Gut microbes and personalized medicine

Our discovery that gut microbes co-evolved with their human hosts offers another way of looking at the human gut microbiome. Gut microbes have been passed between people for hundreds or thousands of generations, so as humans changed, so did their gut microbes. As a result, some gut microbes behave as if they were part of the human genome: they are packages of genes that are passed down between generations and shared by related individuals.

Personalized medicine and genetic testing is beginning to make treatments more specific and effective for the individual. Knowing which microbes have had long-term associations with people can help researchers develop microbiome-based treatments specific to each population. Doctors are already using locally sourced probiotics derived from the gut microbes of community members to treat malnutrition.

Our findings also help scientists better understand how microbes make the ecological and evolutionary transition from “free-living” in the environment to a reliance on conditions in the human gut. Codiversified microbes have traits and genes. reminiscent of bacterial symbionts that live inside insect hosts. These shared characteristics suggest that other animal hosts may also have gut microbes that co-diversified with them throughout evolution.

Paying special attention to the microbes what humans share evolutionary history they can help improve understanding of the role they play in human well-being.


Gut and human microbes on a joint evolutionary journey


Provided by
The conversation


This article is republished from The conversation under a Creative Commons license. Read the Original article.The conversation

Citation: Humans evolved with their microbiomes. Like genes, your gut microbes pass from one generation to the next (September 17, 2022) Retrieved September 17, 2022 at https://phys.org/news/2022-09-humans-evolved-microbiomes -genes-gut.html

This document is subject to copyright. Other than any fair dealing for private study or research purposes, no part may be reproduced without written permission. The content is provided for informational purposes only.


#Humans #evolved #microbiomes #genes #gut #microbes #pass #generation

About Post Author

Happy
Happy
0 %
Sad
Sad
0 %
Excited
Excited
0 %
Sleepy
Sleepy
0 %
Angry
Angry
0 %
Surprise
Surprise
0 %

Average Rating

5 Star
0%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Leave a Reply

Your email address will not be published.

As rates rise, is now the time to secure a fixed mortgage?  This is what you should know - National |  Globalnews.ca Previous post As rates rise, is now the time to secure a fixed mortgage? This is what you should know – National | Globalnews.ca
Danforth Semi Next post What $1 million bought at the peak of the Toronto housing market, and what it will buy today